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Target intelligence / Profile preview
Type II NADH:quinone oxidoreductase (NDH-2)
- Target
- NDH-2
- Molecular classification
- Enzyme, Oxidoreductase, Respiratory Complex
01
Overview
Type II NADH:quinone oxidoreductase is an essential bacterial respiratory enzyme that transfers electrons from cytosolic NAD(P)H to lipid-soluble quinones within the inner cell membrane. Its unique structure—single subunit with FAD cofactor—and lack of proton translocation distinguish it from other respiratory complexes like Complex I. Its absence from mammalian systems underpins its value as an antimicrobial drug target against several pathogenic microorganisms.
02
Mechanism of action
Inhibition of bacterial electron transport chain
03
Biological functions
Electron transportRedox balanceEnergy metabolism
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on other FAD-dependent enzymesDevelopment of resistance in bacteria
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