U2 small nuclear RNA 32, pseudogene (RNU2-32P)

U2 small nuclear RNA 32, pseudogene (RNU2-32P) is a pseudogene in the human genome that resembles the gene encoding U2 small nuclear RNA (snRNA), a core component of the spliceosome involved in pre-mRNA splicing[2][1]. Pseudogenes like RNU2-32P are generally considered non-functional: they typically do not produce a functional RNA or protein product and are not active in key biological processes[3]. The canonical, functional U2 small nuclear RNA genes (such as RNU2-1 and RNU2-2) are critical for proper mRNA processing and genetic stability[2][3][1]. However, RNU2-32P itself is classified as a **pseudogene**, meaning it likely does **not** have a role as a receptor, enzyme, transporter, or other therapeutic target, and it does **not** produce a functional U2 snRNA molecule. There is currently no evidence linking RNU2-32P to particular diseases, drug interactions, or use as a biomarker. **Key notes:** - The functional U2 snRNA genes are important in splicing, but pseudogene copies such as RNU2-32P do not contribute to this function[3][2]. - Some U2 snRNA pseudogenes have been annotated due to sequence similarity to active snRNA genes, but most have no known expression or function[3]. - Other pseudogenes labeled similarly (e.g., RNU2-2P, now re-annotated as functional RNU2-2) have been shown, only after detailed analysis, to be functional genes; however, RNU2-32P lacks such evidence[3]. - RNU2-32P is not considered a therapeutic target.

Other names

RNU2-32PRNA, U2 small nuclear 32, pseudogene