U6 small nuclear RNA 113, pseudogene (RNU6-113P)

U6 small nuclear RNA (snRNA) is a highly conserved non-coding RNA essential for the catalytic step of pre-mRNA splicing as part of the spliceosome, the molecular machine that removes introns from eukaryotic mRNA precursors[3][2]. RNU6-113P, however, is a processed pseudogene of U6 snRNA: it is a DNA sequence in the genome derived from reverse transcription and integration of U6 snRNA but does not produce a functional RNA product[4][5]. Pseudogenes like RNU6-113P are common in vertebrates and represent evolutionary remnants or byproducts of retrotransposon activity and genome dynamics, especially those involving LINE-1 (L1) retrotransposition machinery[4][1][5]. These pseudogenes generally do not encode functional proteins or RNAs, are not involved in biological signaling, and are not considered relevant therapeutic targets. There is no evidence that RNU6-113P has a direct role as a biomarker, safety issue, or disease mechanism. Summary of context and usage: - U6 snRNA is an essential spliceosomal RNA, but RNU6-113P is a pseudogene—an inactivated copy without biological or therapeutic function[2][3][4]. - The origin of such pseudogenes is through retrotransposition events, particularly by the action of LINE-1 elements, which can generate chimeric pseudogenes including fragments of snRNAs[1][4][5]. - "RNU6-113P" does not refer to an active protein, drug target, receptor, or disease gene, and its annotation as a "target" is biologically incorrect. If you seek functional RNA targets involved in splicing, refer to the U6 small nuclear RNA itself, not its pseudogenes.

Other names

RNA, U6 small nuclear 113, pseudogeneRNU6-113P