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U6 small nuclear RNA 1130, pseudogene (RNU6-1130P)
- Target
- RNU6-1130P
- Molecular classification
- Other (processed pseudogene, noncoding RNA derivative)
01
Overview
RNU6-1130P is a human pseudogene cloned from the U6 small nuclear RNA (snRNA) gene family. U6 snRNAs are highly conserved non-coding RNAs essential for the function of the spliceosome, which catalyzes the excision of introns from pre-mRNA in eukaryotes[1][3]. However, the '1130 pseudogene' variant is a nonfunctional, processed pseudogene, meaning it arose via retrotransposition and lacks the ability to produce an active snRNA molecule[2][5]. Unlike canonical U6 snRNA, this pseudogene is not transcribed into a functional RNA and does not participate in RNA splicing, gene regulation, or any other biological mechanism. There is no evidence that RNU6-1130P or similar U6 pseudogenes play any role in disease, signaling, or represent viable drug targets[2]. Pseudogenes like this are numerous in the human genome and primarily serve as evolutionary remnants, occasionally useful for studying retrotransposition dynamics, but not as bona fide molecular targets[2][5].
- Other names
- RNU6-1130PRNA, U6 small nuclear 1130, pseudogene
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