U6 small nuclear RNA 114, pseudogene (RNU6-114P)

RNU6-114P (RNA, U6 small nuclear 114, pseudogene) is a pseudogene that corresponds to the U6 small nuclear RNA (snRNA) family. U6 snRNA is a highly conserved component of the spliceosome, where it plays a central role in the catalysis of pre-mRNA splicing by forming base-pair interactions with other spliceosomal RNAs and positioning substrates for the splicing reaction[1][2][3]. However, as RNU6-114P is a pseudogene, it is a non-functional sequence that resembles a functional U6 small nuclear RNA gene but does not produce a functional RNA product and is not part of the active spliceosome machinery[4][2]. Pseudogenes like RNU6-114P are common for U6 snRNA, acting as genomic "backups" but do not have functional or therapeutic relevance[2]. Thus, RNU6-114P is not considered a drug target, does not have known biological functions, disease roles, or safety concerns, and is typically omitted in target-based research.

Other names

RNA, U6 small nuclear 114, pseudogeneRNU6-114P