U6 small nuclear RNA 146, pseudogene (RNU6-146P)

**RNU6-146P** refers to a human pseudogene derived from the U6 small nuclear RNA (snRNA) gene family. U6 snRNAs are critical components of the spliceosome, forming part of the core machinery required for the excision of introns from pre-mRNA during pre-mRNA splicing[1][2]. However, as a *pseudogene*, RNU6-146P does not produce a functional product and is generally considered transcriptionally inactive. Pseudogenes such as RNU6-146P often arise by gene duplication or retrotransposition events and retain high sequence similarity to their functional counterpart, but they typically contain disabling mutations that prevent them from performing their original biological function[3]. The existence of multiple U6-related pseudogenes is common in the human genome and other vertebrates, reflecting the evolutionary importance of functional U6 and the frequent genomic rearrangement of small non-coding RNA genes[2][3]. There is no evidence that RNU6-146P serves as a therapeutic target, biomarker, or has any clinical pharmacology or safety concerns associated with it.

Other names

RNU6-146PRNA, U6 small nuclear 146, pseudogene