U6 small nuclear RNA 39, pseudogene (RNU6-39P)

RNU6-39P (RNA, U6 small nuclear 39, pseudogene) is a **pseudogene** corresponding to a member of the U6 family of small nuclear RNAs (snRNAs) that participate in the spliceosome-mediated pre-mRNA splicing machinery[2][3][5]. The U6 snRNA itself is essential for splicing, where it helps form the catalytic core of the spliceosome and enables correct processing of precursor mRNAs by mediating specific RNA-RNA interactions[2][3]. However, RNU6-39P is a non-functional, genomically encoded copy (pseudogene) formed via retrotransposition[1][5]. It does not produce a functional RNA or protein product and does not have a direct biological function nor disease association. The formation of these U6 snRNA pseudogenes in the human genome is itself a marker of historical retrotransposition events but has no known role as an actionable therapeutic target, biomarker, or disease driver[5]. There are no drugs targeting this locus, and it is not classified as a receptor, enzyme, transporter, or other canonical pharmaceutical target class. **Key clarifications:** - RNU6-39P is a pseudogene, not a functional gene or protein target. - It is not considered a therapeutic target, biomarker, or disease-associated molecule. - The name refers specifically to a pseudogene copy and not to the canonical U6 snRNA itself. **Note:** If you are interested in the canonical, functional U6 small nuclear RNA, omit the “pseudogene” designation—RNU6 is otherwise essential to splicing, but “RNU6-39P” specifically refers to a transcriptionally inactive, non-functional copy.

Other names

RNU6-39PRNU6-39RNA, U6 small nuclear 39, pseudogene