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UBAP1-MVB12-associated (UMA) domain containing 1 (UMAD1)

Target: UMAD1
Molecular classification: Other, Protein-coding gene

Overview

UBAP1-MVB12-associated (UMA) domain containing 1 (UMAD1) is a protein-coding gene in humans, located on chromosome 7, and characterized by the presence of a UMA domain—a protein region associated with UBAP1 and MVB12 proteins. Its common aliases overlap with long noncoding antisense RNAs transcribed from the RPA3 locus, but the protein function is poorly understood and not classified in standard molecular or therapeutic categories. The gene is referenced in disease association databases for retinitis pigmentosa, but mechanistic links are not described.

Other names: RPA3-AS1RPA3OSRPA3 antisense RNA 1RPA3 opposite strandUBAP1-MVB12-associated (UMA) domain containing protein 1UMAD1

Biological functions

Unknown/Other: No confirmed biological functions are assigned for the protein product in human literature as of September 2025. There is some speculative discussion on generic database aggregators (e.g., suggesting immune regulation roles), but these are not validated in the primary literature.

Disease associations

Retinitis pigmentosa (association noted in GeneCards, but no mechanistic or causative data)Other/Unknown: No established disease roles in literature

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