UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene (UGT1A2P)

UGT1A2P (UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene) is a nonfunctional, duplicated segment of DNA related to the UGT1A family of enzymes but it does not encode an active UDP-glucuronosyltransferase enzyme. While protein-coding UGT1A family members (such as UGT1A1) play crucial roles in phase II drug metabolism by conjugating glucuronic acid to a wide range of endogenous and exogenous substrates, UGT1A2P does not encode a functional protein and thus does not directly contribute to drug metabolism, disease pathways, or therapeutic interventions[4]. The presence of such pseudogenes reflects normal gene evolution, where some duplicated genes accumulate mutations rendering them inactive. Unlike functional UGT1A enzymes, which are clinically important for drug metabolism and diseases such as Gilbert syndrome, UGT1A2P serves no known enzymatic or disease-modifying function and is not a protein-coding gene[4]. UGT1A2P should not be confused with functional members of the UGT1A subfamily[2][5][6].

Other names

UGT1BP