Target intelligence / Profile preview

Urinary pH (Alkalinization) (N/A)

Target
N/A
Molecular classification
Physiological Process, Acid-Base Balance
01

Overview

Urinary alkalinization is a therapeutic strategy aimed at increasing urinary pH, typically to prevent or treat certain types of kidney stones, enhance drug excretion, or manage specific poisonings. It involves manipulating the acid-base balance in the urine to increase the solubility of weak acids, preventing their crystallization and promoting their elimination. This is achieved through dietary modifications or the administration of alkalizing agents such as potassium citrate or sodium bicarbonate. Monitoring urinary pH is crucial to ensure the target range is achieved and maintained, avoiding the risks of over-alkalinization.

Other names
Urine pHUrine AlkalinityUrinary AlkalinityAlkalinizing Urine
02

Mechanism of action

Increases urinary pH, enhancing the solubility and excretion of certain compounds, particularly weak acids like uric acid. Shifts the equilibrium of acid-base reactions in the urine, reducing the concentration of unionized acids, which are more prone to crystallize.

03

Biological functions

Regulation of renal excretionRegulation of acidityMaintenance of acid-base balanceSolubility of weak acids in urine
04

Disease associations

Uric Acid NephrolithiasisDrug ToxicityContrast-Induced Kidney Injury (as a marker, not mediator)
05

Safety considerations

Over-alkalinization (leading to calcium phosphate or struvite stone formation)Gastrointestinal discomfort (bloating, gas)Electrolyte imbalances (with sodium bicarbonate)
06

Interacting drugs

Potassium Citrate

2 more in the full profile.

07

Biomarkers

Urinary pH

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