Uroplakin 3B like 3, pseudogene (UPK3BL3P)

UPK3BL3P (uroplakin 3B like 3, pseudogene) is a pseudogene located on chromosome 7 (CHR: 7:43,984,995-43,990,207, reverse strand, GRCh38)[2]. Pseudogenes are genomic DNA sequences similar to normal genes but generally nonfunctional; they arise from duplication or retrotransposition events and typically do not produce a functional protein. UPK3BL3P is annotated in genome databases as a processed pseudogene not known to encode any protein product or participate in cellular functions. Though related by sequence to the uroplakin gene family (including functional proteins such as uroplakin 3B), UPK3BL3P itself has no known biological or therapeutic significance[2]. Contextual clarifications: - Is this a functional therapeutic target? No, as it is a pseudogene and does not express a protein product. - Is there something incorrect about this target? Yes; if queried as a "target," "receptor," or protein-coding gene, this is misleading. UPK3BL3P is not a protein, receptor, enzyme, or any functional biomolecule. It is not used as a biomarker, therapeutic target, nor associated with any drugs. - Aliases and activity: No common aliases, drugs, or mechanisms are associated with this pseudogene. For molecular and drug discovery purposes, this "target" should be flagged as not suitable and not a valid target. For comparison, a functional family member is Uroplakin 3B (UPK3B, also called UPIIIb, p35)[5][3], which is a cell surface protein expressed in urothelial cells and mesothelium, but UPK3BL3P is not that entity.

Not applicable.