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Target intelligence / Profile preview
Vaccinia virus envelope proteins (VACV envelope proteins) (VACV envelope proteins)
- Target
- VACV envelope proteins
- Molecular classification
- Viral protein, Envelope protein, Glycoprotein
01
Overview
Vaccinia virus envelope proteins are a complex group of viral components that facilitate the assembly, egress, and host-cell entry of the virus (PubMed: 15140260}
- Other names
- Orthopoxvirus envelope proteinsVaccinia virus surface proteinsp37 proteinF13 proteinA33 proteinB5 proteinL1 proteinH3 protein
02
Mechanism of action
Tecovirimat inhibits the p37 envelope protein (encoded by the F13L gene), which is required for the wrapping of intracellular mature virus (IMV) with a Golgi-derived membrane to form the extracellular enveloped virus (EEV), thereby preventing viral egress and spread (PubMed: 30256165).
03
Biological functions
Viral egressViral assemblyMembrane fusionCell-to-cell spreadHost cell attachment
04
Disease associations
InfectionSmallpoxMpoxVaccinia
05
Safety considerations
Development of drug resistance via F13L mutationsPotential for cross-resistance among orthopoxvirusesLimited clinical data in severe disease
06
Interacting drugs
Tecovirimat
1 more in the full profile.
07
Biomarkers
Viral DNA loadp37 (F13L) sequence variantsAnti-vaccinia antibody titers
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