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Vanin 3, pseudogene (VNN3P)
- Target
- VNN3P
- Molecular classification
- Pseudogene (unitary or unprocessed, disrupted by mutation), Family: Amidohydrolases, Other
01
Overview
Vanin 3, pseudogene (VNN3P) is a human genomic locus within the vanin gene cluster on chromosome 6q23-q24. Its open reading frame is disrupted by a frameshift mutation, so it does not encode a functional protein. Extensive alternative splicing exists, but none of the transcripts encode the predicted pantetheinase protein. It is thus classified as a pseudogene and does not exhibit enzymatic activity or serve as a direct target in drug development. It may have limited biological roles in gene regulation (ceRNA/miRNA competition is possible for some pseudogenes, but no evidence for VNN3P specifically). Its significance is in genomic mapping and may be relevant for evolutionary or locus studies, not as a functional protein-coding target.
- Other names
- Vanin 3VNN3HGNC:16431NCBI Gene:55350ENSG00000093134OMIM®:606592HSA238982
02
Mechanism of action
None (Drugs cannot target a pseudogene that does not encode a protein)
03
Biological functions
Does not encode a functional protein in humans; therefore, no direct molecular biological function.Related vanin family genes are involved in coenzyme A metabolism, pantetheinase activity, and production of antioxidant cysteamine, but these functions do not apply to VNN3P itself.
04
Disease associations
Associated with disease by locus proximity or gene cluster: allergic contact dermatitis, autosomal recessive congenital ichthyosisNo direct (active) role in disease as a pseudogene
05
Safety considerations
None (Not pharmacologically targeted; no therapeutic risk)
06
Biomarkers
None directly (Pseudogene expression can sometimes serve as cancer subtype biomarkers, but no evidence supports VNN3P in this role.)
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