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Target intelligence / Profile preview
Varicella-zoster Virus Antigen (Live Attenuated) (VZV (Live Attenuated))
- Target
- VZV (Live Attenuated)
- Molecular classification
- Viral antigen, Live attenuated virus
01
Overview
The varicella-zoster virus (VZV) antigen (live attenuated) is a weakened, replication-competent form of the VZV used in vaccines to prevent varicella (chickenpox) and herpes zoster (shingles). The most widely used strain is the Oka/Merck strain, which induces both humoral and cellular immune responses. After vaccination, the live attenuated virus can establish latency in neural ganglia similar to wild-type VZV. Periodic subclinical reactivation may help maintain long-term immunity by boosting immune memory. While highly safe and attenuated, some safety concerns include a rare mild rash post-vaccination and the potential for transmission of the vaccine strain, especially in immunocompromised individuals.
- Other names
- Oka/Merck strainLive attenuated VZV vaccineVaricella vaccineZoster vaccine
02
Mechanism of action
Stimulates active immunity through controlled viral replication and antigen presentation.
03
Biological functions
Antigen presentationImmune response inductionEstablishment of latencyStimulation of humoral immunityStimulation of cellular immunity
04
Disease associations
Prevention of varicella (chickenpox)Prevention/reduction of herpes zoster (shingles)
05
Safety considerations
Mild rash post-vaccinationPotential for transmission of vaccine strain (rare)Risk of disseminated infection in immunocompromised individuals
06
Interacting drugs
Varicella vaccine (Oka/Merck strain)
1 more in the full profile.
07
Biomarkers
Anti-VZV IgG levelsVZV DNA (PCR)
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