Various immune and hematopoietic cells (via cytokines, exosomes, and adhesion molecules)

The phrase "Various immune and hematopoietic cells via cytokines, exosomes, and adhesion molecules" refers to the integrated network of communication that governs the development and function of the immune system [1]. This system relies on three primary modes of interaction: soluble signaling via cytokines, long-range or paracrine communication via exosomes, and direct cell-to-cell contact through adhesion molecules [2]. Cytokines, such as interleukins and interferons, act as the primary chemical messengers that dictate the activation, proliferation, and differentiation of immune cells [1]. Adhesion molecules, including integrins and selectins, are essential for the structural organization of lymphoid tissues and the recruitment of leukocytes to sites of inflammation [3]. Exosomes contribute to this network by transporting bioactive lipids, proteins, and RNAs between cells, thereby modulating the functional state of distant hematopoietic populations [2]. Dysregulation of these communication pathways is central to the pathogenesis of chronic inflammatory diseases, autoimmune disorders, and the progression of various cancers [4]. While the system as a whole is not a single drug target, many therapeutic agents are designed to intercept specific nodes within this network to restore homeostasis [3].

Other names

Immune-hematopoietic communication networkIntercellular signaling systemCytokine-exosome-adhesion axis

Modulation of intercellular communication through the inhibition or activation of specific cytokines, adhesion molecules, or cellular receptors within the hematopoietic and immune systems [1, 3].