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Target intelligence / Profile preview
Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Family (VEGFR family)
- Target
- VEGFR family
- Molecular classification
- Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase
01
Overview
The vascular endothelial growth factor receptor (VEGFR) tyrosine kinase family comprises cell surface receptors crucial for angiogenesis, vasculogenesis, and lymphangiogenesis. Activation by VEGF ligands triggers dimerization and autophosphorylation, initiating downstream signaling pathways involved in cell proliferation, migration, survival, and vascular permeability. The family includes VEGFR-1 (FLT-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt4), each with distinct ligand specificities and biological functions. Dysregulation is implicated in cancer, making them therapeutic targets for antiangiogenic therapies.
- Other names
- VEGFRVEGFR receptorsVEGF receptors
02
Mechanism of action
Tyrosine kinase inhibition, Ligand sequestration
03
Biological functions
AngiogenesisVasculogenesisLymphangiogenesisCell proliferationCell migrationCell survivalVascular permeabilityBlood vessel formationBlood vessel remodeling
04
Disease associations
CancerTumor angiogenesisRetinal vascular diseases
05
Safety considerations
HypertensionProteinuriaThromboembolic eventsWound healing complications
06
Interacting drugs
Bevacizumab
7 more in the full profile.
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