Vault RNA 2-2, pseudogene (VTRNA2-2P)

**Vault RNA 2-2, pseudogene (VTRNA2-2P)** is an annotated pseudogene of the vault RNA family in the human genome. Pseudogenes are either nonfunctional descendants of functional genes or noncoding regions. VTRNA2-2P is not reported to encode a functional RNA and is distinguished from transcribed and active vault RNAs such as VTRNA2-1. Its promoter region lacks some of the regulatory elements required for efficient transcription present in active vault RNA genes, suggesting that it is not normally expressed as a functional RNA. No biological functions, disease associations, or roles as a therapeutic target have been reported for this pseudogene[1][4]. **Key points:** - The canonical *functional* human vault RNAs are: **VTRNA1-1, VTRNA1-2, VTRNA1-3, and VTRNA2-1**; VTRNA2-2P is not among the functional RNAs[1][2][4]. - VTRNA2-2P is classified as a "pseudogene," denoting that it lacks or has lost biological activity[1]. - Pseudogenes like VTRNA2-2P are *not considered therapeutic targets*, nor do they function as enzymes, receptors, or binding proteins[1][4]. - No drugs, mechanisms of action, safety concerns, or biomarker roles are reported for VTRNA2-2P. **Note on correctness:** This entry refers to a *pseudogene* and not to a known functional RNA or protein target. For therapeutically relevant vault RNA targets, see VTRNA2-1 (also known as pre-miR-886, CBL3). VTRNA2-2P should not be used as a canonical target for therapeutic or biomarker development[1][4].

Other names

VTRNA2-2Pvault RNA pseudogene 2-2