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Target intelligence / Profile preview
Vibrio cholerae (attenuated)
- Molecular classification
- Bacteria, Live attenuated vaccine
01
Overview
Attenuated strains of Vibrio cholerae are genetically modified bacteria used as live oral vaccines to prevent cholera. These strains have reduced virulence due to deletions or mutations in key toxin genes, such as ctxA/ctxB, while retaining the ability to colonize the gut and stimulate a strong immune response, including the production of vibriocidal antibodies and anti-LPS antibodies. This approach provides long-term protection against subsequent infection with wild-type V. cholerae.
- Other names
- Attenuated Vibrio choleraeLive attenuated Vibrio cholerae vaccineV. cholerae (attenuated)
02
Mechanism of action
Induction of humoral and cellular immunity against Vibrio cholerae
03
Biological functions
Antigen presentationImmune response inductionColonization (transient)Antibody production
04
Disease associations
CholeraInfection
05
Safety considerations
Potential for mild diarrheaRisk of reversion to virulence (low)Reactogenicity (reduced in modern strains)
06
Biomarkers
Vibriocidal antibody titersAnti-lipopolysaccharide (LPS) antibody titers
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