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Target intelligence / Profile preview
Vibrio cholerae (O1 and O139) (V. cholerae)
- Target
- V. cholerae
- Molecular classification
- Bacteria, Gram-negative bacteria, Pathogen
01
Overview
Vibrio cholerae is a Gram-negative bacterium that causes cholera, a severe diarrheal disease. Only toxigenic strains from serogroups O1 and O139 are responsible for epidemic and pandemic cholera. The primary virulence factor is cholera toxin (CTX), which causes profuse watery diarrhea. Treatment involves antibiotics and oral rehydration salts.
- Other names
- Vibrio cholerae O1Vibrio cholerae O139Cholera bacteria
02
Mechanism of action
Antibiotics target bacterial cell wall synthesis, protein synthesis, or DNA replication. Oral rehydration salts replenish fluids and electrolytes lost due to diarrhea.
03
Biological functions
ColonizationToxin productionInfectionMotilitySurvival in aquatic environments
04
Disease associations
CholeraGastroenteritisDiarrheal diseaseInfection
05
Safety considerations
Antibiotic resistanceDevelopment of carrier stateSpread of infection via contaminated water/foodPotential for outbreaks and pandemics
06
Interacting drugs
Antibiotics (e.g., tetracycline, doxycycline, azithromycin, ciprofloxacin)
2 more in the full profile.
07
Biomarkers
V. cholerae in stool samples (detection via culture or PCR)Cholera toxin (CTX) detectionO1 and O139 serogroup identificationAntibiotic resistance markers
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