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Target intelligence / Profile preview
Vibrio cholerae (O1 and O139) Whole Cell Antigen
- Molecular classification
- Lipopolysaccharide (LPS), O-antigen, Polysaccharide, Bacterial Surface Antigen
01
Overview
The Vibrio cholerae (O1 and O139) whole cell antigen refers to the complete set of surface antigens present on inactivated V. cholerae cells from these serogroups. It primarily includes lipopolysaccharide (LPS) O-antigens, which differ structurally between O1 and O139 serogroups, as well as other surface-exposed proteins. These antigens are crucial components of oral cholera vaccines, inducing protective immunity through the generation of antibodies against V. cholerae.
- Other names
- V. cholerae O1 Whole Cell AntigenV. cholerae O139 Whole Cell AntigenKilled V. cholerae O1/O139Vibrio cholerae O1 LPS/O-antigenVibrio cholerae O139 LPS/O-antigen
02
Mechanism of action
Stimulation of humoral immunity (IgG, IgM, IgA) against V. cholerae O1 and O139 surface antigens, particularly LPS/O-antigen, leading to vibriocidal antibody production and protective immunity.
03
Biological functions
Immune response inductionAntibody productionVibriocidal activity inductionProtective immunity
04
Disease associations
CholeraInfectionVaccine target
05
Safety considerations
Reactogenicity (mild fever, diarrhea)Efficacy may vary based on pre-existing immunity
06
Interacting drugs
Oral cholera vaccines (e.g., Dukoral, Shanchol, Euvichol-Plus)
07
Biomarkers
Anti-LPS/OSP IgG levelsVibriocidal antibody titers
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