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Viral DNA Polymerase (Herpesviruses) (None)
- Target
- None
- Molecular classification
- Enzyme, B-family DNA Polymerase
01
Overview
Viral DNA polymerase is a key enzyme encoded by herpesviruses, essential for viral genome replication during the lytic phase of infection. It belongs to the B family of DNA polymerases and is a primary target for antiviral drugs. The enzyme typically functions as part of a two-subunit complex, responsible for high-fidelity synthesis of viral genomic DNA. It possesses DNA polymerase, 3′–5′ exonuclease proofreading, and ribonuclease H activities. All current anti-herpetic drugs targeting HSV or HCMV act on their respective viral DNA polymerases.
02
Mechanism of action
Inhibition of viral DNA polymerase activity after phosphorylation inside infected cells.
03
Biological functions
DNA replicationGenome replicationProofreadingRibonuclease activity
04
Disease associations
Infection
05
Safety considerations
Drug resistanceMutations in kinase/polymerase genesChallenges in immunocompromised patients
06
Interacting drugs
Acyclovir
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