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Target intelligence / Profile preview
Virus-infected cells presenting Epstein–Barr virus (EBV) antigens (EBV-infected cells)
- Target
- EBV-infected cells
- Molecular classification
- Cell, Virus-infected cell, Antigen-presenting cell
01
Overview
Virus-infected cells presenting Epstein–Barr virus antigens are primarily human B lymphocytes and, to a lesser extent, epithelial cells that have been infected by EBV. These infected cells display viral proteins (antigens) on their surface via major histocompatibility complex (MHC) molecules, making them recognizable to the immune system—particularly cytotoxic T lymphocytes and natural killer (NK) cells.
- Other names
- EBV-positive cellsEpstein-Barr virus infected B lymphocytesEBV antigen-presenting cells
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationImmune stimulationViral replicationCell proliferationImmune evasion
04
Disease associations
Infectious mononucleosisPost-transplant lymphoproliferative disorderHodgkin lymphomaNon-Hodgkin lymphomaEBV-associated malignancies
05
Safety considerations
Potential for off-target effects on non-infected cellsRisk of cytokine release syndromeDevelopment of resistance to therapy
06
Biomarkers
EBV DNA loadEBV antigen expression (e.g., LMP1, EBNA2)
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