VMA21 vacuolar H+-ATPase homolog pseudogene (null)

ENSG00000282413 encodes a **pseudogene** of the VMA21 vacuolar H+-ATPase homolog. Unlike the protein-coding VMA21 gene (which is required for assembly of the V0 complex of vacuolar ATPase and whose deficiency leads to X-linked myopathy with excessive autophagy), this pseudogene is **non-protein coding** and does not perform known biological functions or act as a therapeutic target[4]. It should be distinguished from the protein-coding VMA21 gene, which is the relevant molecular target in disease biology[2][3][4]. Additional context and clarification: ENSG00000282413 is annotated in Ensembl as a pseudogene, and does not produce a functional protein[4]. The canonical therapeutic target relevant in literature is the protein-coding **VMA21 (Vacuolar ATPase Assembly Factor VMA21)**, not this pseudogene[2][3][7]. If the intended query is the active protein-coding VMA21 gene, refer instead to “VMA21 vacuolar ATPase assembly factor”[2][7]. There are no reported drugs, biomarkers, or therapeutic mechanisms associated with this pseudogene. Summary of guidance: This pseudogene (ENSG00000282413) is **not a therapeutic target**, has **no reported biological or drug-related function**, and should **not be used in lieu of the protein-coding VMA21 gene** for molecular or therapeutic studies[4].

Other names

VMA21 pseudogeneVMA21 vacuolar H+-ATPase homolog (S. cerevisiae) pseudogene[4]