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Target intelligence / Profile preview
High-Voltage-Activated Calcium Channel (HVA Calcium Channel)
- Target
- HVA Calcium Channel
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel, L-type calcium channel, N-type calcium channel, P/Q-type calcium channel, R-type calcium channel
01
Overview
High-voltage-activated (HVA) calcium channels are a class of voltage-gated ion channels that open in response to strong depolarizations of the cell membrane. Their activation allows the influx of Ca²⁺ ions, which serve as critical second messengers for numerous physiological processes, including muscle contraction, neurotransmitter and hormone secretion, gene transcription, and synaptic transmission. The HVA calcium channel family includes several subtypes distinguished by their biophysical properties and pharmacological sensitivities: L-type (Cav1.1–Cav1.4), P/Q-type (Cav2.1), N-type (Cav2.2), R-type (Cav2.3). Each subtype has specialized roles depending on tissue distribution.
- Other names
- Voltage-Gated Calcium Channel (VGCC)High-Threshold Calcium Channel
02
Mechanism of action
Channel blockade
03
Biological functions
Calcium ion transportExcitation-contraction couplingNeurotransmitter releaseHormone secretionGene transcriptionSignal transductionSynaptic transmission
04
Disease associations
Neurological disordersCardiovascular diseasePainEpilepsyAtaxiaMigraine
05
Safety considerations
Cardiovascular side effects (L-type channel blockers)Neurological side effects (N-type channel blockers)Drug interactions
06
Interacting drugs
Dihydropyridines
2 more in the full profile.
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