Voltage-gated sodium channel (tetrodotoxin-sensitive) (TTX-s Nav) (TTX-s Nav)

Voltage-gated sodium channels (Nav) are integral membrane proteins that facilitate the rapid influx of sodium ions, a process fundamental to the generation and propagation of action potentials in neurons and muscle cells [UniProt]. The tetrodotoxin-sensitive (TTX-s) subtype group specifically refers to channels (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7) that are inhibited by nanomolar concentrations of tetrodotoxin, a potent neurotoxin [PubMed: 25455072]. These channels are primarily expressed in the central and peripheral nervous systems and skeletal muscle, where they regulate excitability and signal transmission [StatPearls: NBK540971]. Dysregulation or mutations in the genes encoding these channels, such as SCN1A or SCN9A, are associated with a wide range of disorders, including epilepsy, chronic pain syndromes like erythromelalgia, and motor dysfunction [NIH: Genetics Home Reference]. Therapeutic agents targeting these channels include local anesthetics, anticonvulsants, and antiarrhythmics, which typically act by blocking the channel pore or stabilizing the non-conducting inactivated state to reduce hyper-excitability [IUPHAR/BPS Guide to Pharmacology].

Other names

TTX-sensitive sodium channelTetrodotoxin-sensitive voltage-gated sodium channelNav1.1Nav1.2Nav1.3Nav1.4Nav1.6Nav1.7SCN1ASCN2ASCN3ASCN4ASCN8ASCN9ATTX-s sodium channelTTX-s Nav

Inhibition of sodium ion influx through the channel pore, typically by binding to the local anesthetic receptor site within the pore or by stabilizing the inactivated state of the channel.