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Target intelligence / Profile preview
Wall Teichoic Acid (β-N-acetylglucosamine Modification) (WTA-β-GlcNAc)
- Target
- WTA-β-GlcNAc
- Molecular classification
- Glycopolymer, Cell Wall Component, Polysaccharide
01
Overview
Wall teichoic acids (WTAs) are major anionic glycopolymers found in Gram-positive bacteria. The β-N-acetylglucosamine (β-GlcNAc) modification of WTA, catalyzed by TarS, is crucial for cell wall integrity, antibiotic resistance (especially to β-lactams in MRSA), phage sensitivity, and immune recognition. Targeting TarS or the β-GlcNAc modification itself is a potential strategy for sensitizing resistant bacteria to antibiotics and enhancing immune clearance.
- Other names
- β-GlcNAc-modified WTAWTA glycosylationTarS substrate
02
Mechanism of action
Sensitization to β-lactam antibiotics upon TarS inhibition or WTA-β-GlcNAc modification disruption.
03
Biological functions
Cell wall integrityAntibiotic resistancePhage sensitivityImmune recognitionBacterial Morphogenesis
04
Disease associations
Methicillin-resistant Staphylococcus aureus (MRSA) infectionStaphylococcus aureus infectionListeria monocytogenes infection
05
Safety considerations
Potential for off-target effects if targeting WTA biosynthesisDevelopment of resistance to new therapies targeting WTA modification
06
Interacting drugs
β-lactam antibiotics
07
Biomarkers
Presence/absence of WTA-β-GlcNAc modification
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