WASP homolog-associated protein with actin, Golgi membranes and microtubules (WHAMM)

WHAMM (WASP homolog-associated protein with actin, Golgi membranes and microtubules) is a cytoskeletal regulator that acts as a nucleation-promoting factor stimulating actin filament polymerization via the Arp2/3 complex, primarily at the Golgi apparatus and on tubular membranes. It is essential for membrane tubulation, vesicle transport between the endoplasmic reticulum and Golgi, and maintenance of Golgi positioning near the centrosome. WHAMM binds microtubules and F-actin, integrating actin and membrane remodeling for cellular processes such as cell adhesion and migration. Mutations in WHAMM are associated with rare syndromes involving immune deficiency and developmental abnormalities. WHAMM operates downstream of RhoD GTPase during cytoskeletal reorganization, and its activities are coordinated with those of related proteins such as JMY. No drugs are yet described to specifically target WHAMM. While WHAMM is not a common drug target (such as a receptor, enzyme, or transporter), its molecular functions are fundamentally important for cellular architecture and dynamics. The provided target name is correct, though standardized as "WASP homolog-associated protein with actin, Golgi membranes and microtubules (WHAMM)".

Other names

WAS Protein Homolog Associated With Actin, Golgi Membranes And MicrotubulesWASP Homolog-Associated Protein With Actin, Membranes And MicrotubulesWH2 Domain-Containing Protein 1WAS Protein Homology Region 2 Domain-Containing Protein 1WHDC1 (previous HGNC symbol)