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Target intelligence / Profile preview
Wilms' Tumor 1 Protein (WT1)
- Target
- WT1
- Molecular classification
- Transcription factor, Zinc finger protein, RNA-binding protein
01
Overview
Wilms' tumor 1 protein (WT1) is a zinc finger transcription factor that plays a crucial role in urogenital system development. It functions as both a tumor suppressor and an oncogene, depending on the cellular context. Mutations or altered expression are implicated in several cancers, including Wilms’ tumor and acute myeloid leukemia. WT1 regulates gene expression and RNA metabolism, influencing cell growth, differentiation, apoptosis, and organ development. It is also a diagnostic marker for certain tumors.
- Other names
- Wilms tumor proteinWT1 proteinNephroblastomaWTI
02
Mechanism of action
Modulation of WT1 expression or activity; inhibition of WT1 function; immunotherapy targeting WT1
03
Biological functions
Transcriptional regulationRNA bindingCell growthDifferentiationApoptosisOrgan developmentEpigenetic regulation
04
Disease associations
CancerWilms' tumorAcute myeloid leukemia (AML)Denys–Drash syndromeMesotheliomaOvarian serous carcinomaHernias
05
Safety considerations
Potential for off-target effects due to widespread expressionComplex and context-dependent function makes therapeutic targeting challenging
06
Biomarkers
Minimal residual disease monitoring in AMLImmunohistochemical detection in mesothelioma and ovarian carcinomaWT1 expression levels in AML
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