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Target intelligence / Profile preview
Wilms' tumor gene 1 protein (WT1)
- Target
- WT1
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Wilms' tumor gene 1 protein (WT1) is a zinc finger transcription factor crucial for kidney and gonad development during embryogenesis. It regulates genes involved in cell growth, differentiation, and apoptosis. WT1 acts as both a tumor suppressor and an oncogene, depending on the cellular context, and is implicated in various diseases, including Wilms' tumor, Denys–Drash syndrome, WAGR syndrome, and leukemia. Its expression is used diagnostically, and it's a promising target for cancer immunotherapy.
02
Mechanism of action
Immunotherapies targeting WT1 epitopes induce cytotoxic T lymphocyte activity; Modulation of proliferation/differentiation/apoptosis via gene regulation; Activation of pro-growth pathways (e.g., PI3K/AKT)
03
Biological functions
Organ developmentCell growthCell differentiationApoptosisRegulation of gene expression
04
Disease associations
CancerWilms' tumorLeukemiaDenys–Drash SyndromeWAGR Syndrome
05
Safety considerations
Potential for off-target effects with immunotherapyDual role as tumor suppressor and oncogene necessitates careful consideration in therapeutic targeting
06
Biomarkers
Minimal residual disease detectionImmunohistochemical marker for mesothelioma vs adenocarcinoma
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