Y+L amino acid transporter 1 (SLC7A7)

Y+L amino acid transporter 1 (encoded by SLC7A7) is the light subunit of a sodium-independent, heterodimeric cationic amino acid transporter, which associates with the heavy chain SLC3A2 to form system y+L. This system facilitates the bidirectional exchange of cationic amino acids (notably lysine, arginine, ornithine) and large neutral amino acids across epithelial cell membranes in the intestine and kidney, playing an essential role in amino acid homeostasis. Mutations in SLC7A7 disrupt this transport, causing lysinuric protein intolerance (LPI), an autosomal recessive disorder with symptoms derived from defective absorption and reabsorption of basic amino acids. Beyond its role in amino acid transport, SLC7A7 also modulates immune responses in monocytes/macrophages and is implicated in disease states such as tumor progression and disorders of pregnancy[1][2][4][5][6].

Other names

Y+L amino acid transporter 1SLC7A7Y+LAT1y+LAT-1LAT3LPIMOP-2Monocyte amino acid permease 2y(+)L-type amino acid transporter 1solute carrier family 7 member 7solute carrier family 7 (amino acid transporter light chain, y+L system), member 7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

Substrate competition for transport (as in high-dose amino acid supplementation); Restoration or bypassing of defective transport function (in LPI via therapeutic diet)