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Target intelligence / Profile preview
Zinc Finger Nuclease (ZFN) (ZFN)
- Target
- ZFN
- Molecular classification
- Engineered protein, Nuclease, Transcription factor (engineered)
01
Overview
Zinc finger nuclease-mediated genome editing is an advanced molecular tool that enables targeted modification of genomes through programmable recognition and cleavage at user-specified sites. It has paved the way for precise genetic engineering across many fields but faces competition from newer technologies due to challenges with design complexity and off-target risks. Nonetheless, it remains significant both as a foundational technology in genome engineering history and as an option where high specificity is required or alternative methods are less suitable.
- Other names
- Engineered restriction enzymeArtificial restriction enzymeProgrammable nuclease
02
Mechanism of action
Targeted DNA double-strand break induction via zinc finger-mediated DNA binding and FokI nuclease dimerization.
03
Biological functions
Genome editingDNA cleavageGene disruptionGene insertionTargeted mutagenesis
04
Disease associations
Genetic diseaseInfectious diseaseCancer
05
Safety considerations
Off-target effects (unintended DNA cleavage)Immunogenicity (immune response to the engineered protein)Mosaicism (incomplete gene editing in all cells)Unintended genomic rearrangements
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