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Target intelligence / Profile preview
Zinc finger protein, FOG family member 2 (ZFPM2)
- Target
- ZFPM2
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein, FOG family member 2 (ZFPM2; also known as FOG2) is a multi-zinc finger transcriptional cofactor that interacts with GATA transcription factors (especially GATA4, GATA2, GATA5, GATA6), modulating their ability to activate or repress gene expression[1][2][3
- Other names
- FOG2FOG-2Friend of GATA2Friend of GATA protein 2ZNF89BZC2HC11BDIH3SRXY9hFOG-2
02
Biological functions
Modulation of transcription factor activityRegulation of cardiac development and morphogenesisRegulation of gonad and diaphragm developmentRegulation of cell growth and proliferationRegulation of metabolic pathways and hematopoiesisModulation of insulin signaling and PI3K pathway
03
Disease associations
Congenital heart disease (including Tetralogy of Fallot, double outlet right ventricle, truncus arteriosus, interrupted aortic arch)Congenital diaphragmatic herniaDisorders of sex development/ambiguous genitaliaHematologic malignancies (via fusion genes in myelodysplasia)Cancer (including lung adenocarcinoma, glioma, ovarian tumors)
04
Safety considerations
Potential for embryonic lethality and developmental defects when functionally disruptedHaploinsufficiency may lead to organ malformation and developmental disease
05
Biomarkers
ZFPM2 expression levels (in congenital heart disease, congenital diaphragmatic hernia, selected cancers)
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