Zinc finger protein 286B (pseudogene) (ZNF286B)

Zinc finger protein 286B (pseudogene) is a non-protein-coding gene, originally annotated based on sequence similarity to zinc finger transcription factors, but it is not expressed as a functional protein in humans. The locus has alternative aliases including ZNF286C and FOXO3B, but its status as a pseudogene means it is not considered a therapeutic target and does not contribute to biological activity, disease mechanisms, or drug response. Some gene prediction databases annotate potential DNA-binding or transcriptional regulatory activity by homology, but in practice, this is not realized in vivo as the region does not encode a functional protein. ENSG00000273704 is best described as a nonfunctional pseudogene, not a gene or protein target for therapy. It is not a receptor, enzyme, transporter, or active transcription factor. Pseudogenes like ZNF286B are sometimes mis-annotated in target lists or algorithms due to sequence similarity, but are not druggable nor associated with disease or therapeutic function. Aliases and alternative symbols exist due to historical annotations and homology.

Other names

Zinc finger 286C pseudogeneZinc finger protein 590Zinc finger protein 286-likeForkhead box O3BFOXO3BZNF286LZNF286C