Zinc transporter 1 (ZnT1) (hZnT1)

Human Zinc transporter 1 (hZnT1), encoded by the SLC30A1 gene, is a primary plasma membrane-localized zinc exporter essential for maintaining cellular zinc homeostasis [1, 4]. It functions as a cation diffusion facilitator, mediating the efflux of zinc ions from the cytoplasm to the extracellular space, often through exchange with protons or calcium ions [1, 2]. Beyond its role in zinc transport, hZnT1 acts as a negative regulator of L-type calcium channels and modulates signaling pathways such as the Ras-Raf-ERK cascade [2, 12]. Dysregulation of hZnT1 is implicated in various diseases, including cervical cancer, where its overexpression promotes tumor cell proliferation, metastasis, and resistance to chemotherapy [6, 12]. Somatic mutations in SLC30A1 have also been linked to primary aldosteronism by causing abnormal ion currents and increased aldosterone production [17]. Recent pharmacological studies have identified Bardoxolone methyl as a potent inhibitor of hZnT1, offering a potential therapeutic strategy for cancers overexpressing this transporter [6]. However, because hZnT1 is ubiquitously expressed and essential for embryonic development, therapeutic modulation of this target presents significant safety challenges [1, 2].

Other names

SLC30A1Solute carrier family 30 member 1ZNT1ZRC1

Zinc transporter 1 inhibition