Zyg-11 family member A, cell cycle regulator pseudogene 1 (ZYG11AP1)

Zyg-11 family member A, cell cycle regulator pseudogene 1" (ZYG11AP1) is annotated as a pseudogene in the human genome. There is no scientific evidence supporting its role as a functional protein-coding gene, therapeutic target, or drug interaction partner. The functional ZYG11A and ZYG11B proteins are implicated in regulating the cell cycle by mediating the degradation of cyclin B1 via the CRL2^ZYG11A/B^ ubiquitin ligase pathway, playing a role in mitosis and cell division, but ZYG11AP1 itself does not encode a known active protein or therapeutic target[2][4]. Additional Context: - ZYG11A and ZYG11B are the functional homologs involved in cell cycle control, but ZYG11AP1 is specifically labeled as a pseudogene, meaning it is not typically expressed as a functional protein and is not referenced as a druggable target in the scientific literature[2]. - There is limited to no literature referring to ZYG11AP1 beyond its genetic annotation as a pseudogene[2]. Summary judgment: ZYG11AP1 is a pseudogene, not a functional gene or target, and has no recognized role as a therapeutic target or in disease biology. The actual relevant proteins in human cell cycle regulation are ZYG11A and ZYG11B[4].

Other names

Possibly ZYG11A pseudogene 1