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454 Life Sciences pioneered high-throughput DNA sequencing with its sequencing-by-synthesis platform, commercialized as the first 'next-generation' sequencing system (GS20, GS FLX). Achieved milestones such as the sequencing of the first Neanderthal genome and James Watson's genome, but no therapeutic clinical trials were conducted as the company was a technology platform provider, not a therapeutics developer.[2][3][1]
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