ADDPLAN

ADDPLAN is a leading provider of statistical software and consulting services focused on the design, simulation, and analysis of adaptive clinical trials. Originally founded as an independent company in Cologne, Germany, it was acquired by Aptiv Solutions and subsequently became a core business unit within ICON plc. The ADDPLAN software suite is recognized as the industry standard for implementing complex trial designs, including group sequential designs, sample size re-estimation, and population enrichment. Its tools are utilized by major pharmaceutical companies and global regulatory agencies, such as the FDA and EMA, to evaluate and validate adaptive trial submissions. By enabling data-driven modifications during a trial's progress, ADDPLAN helps sponsors optimize clinical development timelines and improve the probability of success.