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Adge Pharmaceuticals is developing elocalcitol (RO269228), an orally available vitamin D receptor agonist small molecule originally developed by Roche, now being evaluated preclinically for obesity, metabolic syndrome, Rett syndrome, and osteogenesis imperfecta; historical clinical data exist in other indications from prior Roche phase 2 studies, but Adge’s current rare-disease and metabolic programs remain preclinical.[1][3][8][13]
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