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AEIR Therapeutics is a clinical-stage biotechnology company focused on developing novel small molecule inhibitors targeting the Aryl Hydrocarbon Receptor (AHR) for the treatment of cancer. The company's lead program, AEIR-101, is designed to modulate the immune system's response to tumors by blocking the immunosuppressive effects of AHR activation in the tumor microenvironment. By inhibiting AHR, AEIR Therapeutics aims to enhance the efficacy of existing immunotherapies and provide new treatment options for patients with refractory solid tumors. The company's research is based on foundational work regarding the role of AHR in immune regulation and oncogenesis conducted at Pennsylvania State University.
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