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The company's lead candidate, AEVI-001 (fasoracetam), failed to meet the primary endpoint in a Phase 2 trial (SAGA study) for ADHD in patients with metabotropic glutamate receptor (mGluR) gene mutations. Following this, the company pivoted to AEVI-002, which demonstrated proof-of-concept in early trials for pediatric Crohn's disease prior to the company's acquisition.
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