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Agastra is a pre-clinical stage biotechnology company focused on developing next-generation RNA-based therapies for cardiovascular diseases, specifically heart failure. Co-founded by leading researchers from the University of Pennsylvania, including Dr. Thomas Cappola and Dr. Kiran Musunuru, the company leverages mRNA and potentially circular RNA (circRNA) technology to restore cardiac function. Agastra's approach involves the delivery of therapeutic RNA to the heart to express proteins that can repair or improve the performance of failing heart tissue. The company is part of the growing ecosystem of RNA therapeutics startups emerging from academic research in Philadelphia and is supported by PCI Ventures.
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