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AKSO’s lead programs are in late preclinical development. AB001, a first-in-class soluble BCMA decoy receptor targeting APRIL and BAFF, has shown efficacy in mouse models of multiple myeloma and DLBCL with good safety in non-human primates. AB002 is a bi-functional fusion protein that neutralizes PD-L1/PD-L2 and activates NK cells via an IL‑15 agonist; it is being developed for solid tumors through a partnership for Asia-Pacific ex-Japan.
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