Company intelligence / Profile preview
Alethia Biotherapeutics
Montreal, Quebec, Canadaalethiabio.com ↗
- Ownership
- Private
- Employees
- ~12
- Development stage
- Other
01
Overview
Alethia’s lead antibody sotevtamab (formerly AB-16B5) targets EMT by inhibiting secreted clusterin. In preclinical models, it reduced tumor invasion and improved chemotherapy response. Phase I trials showed safety/tolerability with stable disease in several patients up to one year. A completed open-label Phase II trial in NSCLC demonstrated efficacy signals; a new proof-of-concept Phase II trial in colorectal cancer with liver metastases has been initiated. Recent data from the EGIA-002 trial were presented at ASCO 2024.
- Therapeutic areas
- Oncology
- Modalities
- monoclonal antibodies (mAbs), specifically humanized IgG2 antibodies
- Industry
- Biotech
02
Drug pipeline
3 assets2 more assets in the full pipeline.
03
Partnerships
Manufacturing partnership with Goodwin Biotechnologies for AB‑16B5 productionlicensing agreement with National Research Council Biotechnology Research Institute for anti-clusterin mAbs and diagnostic peptide P3378
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