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IMCIVREE (setmelanotide) is commercially approved for rare genetic obesity disorders including POMC, LEPR, and PCSK1 deficiencies, Bardet-Biedl, and Alström syndromes. Phase 3 completed in hypothalamic obesity with 20% placebo-adjusted weight loss; Phase 2 oral cetmelanotide data expected Q3 2025; ongoing studies in Prader-Willi syndrome.[1][2]
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