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The lead program, pegcrisantaspase (Asparec), reached Phase 2/3 clinical trials for patients with acute lymphoblastic leukemia (ALL) who have hypersensitivity to E. coli-derived L-asparaginase. It showed preclinical evidence of being longer-acting and less immunogenic than earlier Erwinia-derived products. The drug received Fast Track and Orphan Drug designations in the US and EU[2][1].
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