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Alliance Discovery is a pre-clinical stage biotechnology company based at the Pennsylvania Biotechnology Center in Doylestown, Pennsylvania. The company focuses on the design, synthesis, and development of novel small-molecule therapeutics targeting chemokine receptors to prevent and treat cancer metastasis. Its lead program centers on CX3CR1 antagonists, including the potent and selective small-molecule inhibitors JMS-17-2 and JMS-FX-68, which have demonstrated efficacy in impairing the seeding and colonization of circulating tumor cells in preclinical models of breast, prostate, and pancreatic cancers.
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