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AlloMek's lead asset, CIP-137401—a proprietary macrocyclic MEK 1/2 inhibitor—demonstrated robust preclinical proof of concept in neurofibromatosis type 1 and LMNA cardiomyopathy models, showing strong potency, safety, and pharmacokinetic profile. IND-enabling toxicology studies were completed and it received orphan designation for NF1, but no clinical trials were started before acquisition by Pasithea Therapeutics.
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