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Amalyte Pharmaceuticals was a clinical-stage biotechnology company focused on developing therapies for metabolic and inflammatory diseases. The company's lead asset was MBX-2982, an oral, potent, and selective agonist of G protein-coupled receptor 119 (GPR119). Amalyte was specifically advancing MBX-2982 for its potential to prevent hypoglycemia in patients with type 1 diabetes by enhancing the secretion of glucagon-like peptide-1 (GLP-1) and other incretins. In October 2019, Amalyte was acquired by CymaBay Therapeutics, which sought to re-integrate MBX-2982 into its own clinical pipeline.
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