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Amunix Pharmaceuticals

South San Francisco, California, United Statessanofi.com ↗

Ownership: Private
Employees: ~39
Development stage: Preclinical

Overview

Amunix has developed a pipeline of masked T cell engagers and cytokines using its proprietary Pro-XTEN/XPAT/XPAC platforms. The lead candidate, AMX‑818, targets HER2-expressing solid tumors and is in IND-enabling studies. Other programs include PSMA-XPAT and EGFR-XPAT. The company’s masking technology aims to reduce toxicity by activating drugs preferentially within the tumor microenvironment. Clinical results are not yet available as the main candidates are preclinical or entering early clinical development.

Therapeutic areas: Oncology
Modalities: T cell engagers (TCEs)CytokinesBi-specific antibodies
Industry: Biotech

Drug pipeline

1 asset

AMX-818

Pre-clinical

Indications: HER2-expressing solid tumors

Partnerships

Roche (licensing deal worth up to $1.5 billion; $40 million upfront)Sanofi (acquirer and current parent company)

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