Company intelligence / Profile preview
Amygdala Neurosciences
San Francisco / Palo Alto, California, United Statesamygns.com ↗
- Ownership
- Private
- Development stage
- Preclinical
01
Overview
Amygdala Neurosciences has advanced two proprietary small molecule ALDH2 inhibitors—ANS‑6637 and ANS‑858—for the treatment of substance use disorders. ANS‑6637 has completed extensive Phase 1 studies in over 150 subjects and entered multiple NIH-funded Phase 2 trials targeting alcohol, opioid, nicotine, and cocaine dependence. Preclinical data show reduction in drug-seeking behavior across several addiction models. The company recently selected ANS‑858 as its next clinical candidate with IND-enabling work underway for first-in-human studies targeting craving reduction in SUDs.[3][6][8]
Early clinical results indicate safety/tolerability with ongoing efficacy evaluation.
Pipeline breadth: At least two main programs identified.
- Therapeutic areas
- Psychiatry
- Modalities
- Small molecules (notably selective and reversible ALDH2 inhibitors)[3][6][8]
- Industry
- Biotech
02
Drug pipeline
2 assets1 more asset in the full pipeline.
03
Partnerships
National Institutes of Health/NIAAA/NIH HEAL InitiativeInstitute of Human Virology at University of Maryland School of MedicineNIH Clinical Center [8][10]
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